Dr. Mario

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Dr. Mario is the new test drive of the new vitamins Mario had recently developed.


“Hi everybody! I'm Mario. How's it going? Over the last few years, I've been involved in some pretty wild adventures. Now, believe it or not, I work in the virus research lab at the Mushroom Kingdom Hospital. Today I'm about to begin my research as usual.[1]
Mario, Dr. Mario

One day, Nurse Toadstool alerts Dr. Mario that the viruses in the virus research lab are spreading quickly due to an out-of-control experiment. Luckily, Mario had just developed a new vitamin that he believes should be able to take care of the viruses.

The medicine proved a successful test drive, and the defeated viruses escape via UFO; the viruses turns out to have extraterrestrial origins.[2]


  • Mario states that over the last few years he’s been “involved in some pretty wild adventures”, but right now he’s working with Peach in the virus research lab in the Mushroom Kingdom Hospital, placing this game after at least a few of the previous Mushroom Kingdom adventures.
  • Mario is still calling Princess Peach “Princess Toadstool”, perhaps implying they aren’t yet on a first-name basis.
  • The Megavitamins are invented in this game, placing it before future Dr. Mario titles.
  • The viruses first appear here, placing this game before future titles featuring the viruses such as Mario & Luigi: Superstar Saga.

See also